Ultimate Spider-Man (2000-2009; 2011) #153

Plot

The Black Cat, having recently stolen the Zodiac Key from the office of the late Wilson Fisk, is visited by Mysterio, who hopes to persuade her to hand it over to him. Felicia refuses and, in an attempt to attack Mysterio, accidentally levels many city blocks with the Zodiac Key.

Meanwhile, Tony Stark is giving his first superhero lesson to Peter Parker when they are alerted to the blast and, together, head to investigate.