Marvel Knights: Spider-Man Vol. 1 (2004-2006) / The Sensational Spider-Man Vol. 2 (2006-2007) #23

Plot

Join new creative team Angel Medina (SPAWN) -- yes, Angel Medina!-- and Roberto Aguirre-Sacasa (MK 4, Nightcrawler) as they take everyone's favorite wall-crawler on a blood-curdling journey into the heart of darkness.

Strange changes are coming over Spidey's animalistic foes - including Dr. Curt Connors, John Jameson, and Felicia Hardy - awakening the beast that dwells within them all. Sure, Spidey's beaten the Lizard, Man-Wolf, and The Black Cat before, but they've never been more vicious than they are now!